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Article

p53: 800 million years of evolution and 40 years of discovery.

Nature reviews. Cancer - 1 Aug 2020

Levine Arnold J

Abstract excerpt

The evolutionarily conserved p53 protein and its cellular pathways mediate tumour suppression through an informed, regulated and integrated set of responses to environmental perturbations resulting in either cellular death or the maintenance of cellular homeostasis. The p53 and MDM2 proteins form a central hub in this pathway that receives stressful inputs via MDM2 and respond via p53 by informing and altering a...

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Source

Identifiers

PMID: 32404993
DOI: 10.1038/s41568-020-0262-1

Genes

MDM2
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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