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Article

Prevalence, causes and impact of TP53-loss phenocopying events in human tumors.

BMC biology - 24 Apr 2023

Fito-Lopez Bruno, Salvadores Marina, Alvarez Miguel-Martin, Supek Fran

Abstract excerpt

BACKGROUND: TP53 is a master tumor suppressor gene, mutated in approximately half of all human cancers. Given the many regulatory roles of the corresponding p53 protein, it is possible to infer loss of p53 activity - which may occur due to alterations in trans - from gene expression patterns. Several such alterations that phenocopy p53 loss are known, however additional ones may exist, but their identity and...

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Identifiers

PMID: 37095494
DOI: 10.1186/s12915-023-01595-1
PMCID: PMC10127307

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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