Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

doi:10.1038/s44320-024-00032-x

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Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

Molecular systems biology - 1 Jun 2024

Lü YiQing, Cho Tiffany, Mukherjee Saptaparna, Suarez Carmen Florencia, Gonzalez-Foutel Nicolas S, Malik Ahmad, Martinez Sebastien, Dervovic Dzana, Oh Robin Hyunseo, Langille Ellen, Al-Zahrani Khalid N, Hoeg Lisa, Lin Zhen Yuan, Tsai Ricky, Mbamalu Geraldine, Rotter Varda, Ashton-Prolla Patricia, Moffat Jason, Chemes Lucia Beatriz, Gingras Anne-Claude, Oren Moshe, Durocher Daniel, Schramek Daniel

Abstract excerpt

Tumor suppressor p53 (TP53) is frequently mutated in cancer, often resulting not only in loss of its tumor-suppressive function but also acquisition of dominant-negative and even oncogenic gain-of-function traits. While wild-type p53 levels are tightly regulated, mutants are typically stabilized in tumors, which is crucial for their oncogenic properties. Here, we systematically profiled the factors that regulate...

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PMID: 38580884
DOI: 10.1038/s44320-024-00032-x
PMCID: PMC11148184

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