Article

Neuroimmune characterization of optineurin insufficiency mouse model during ageing

2023-03-12

Abstract excerpt

Optineurin is a multifunctional polyubiquitin-binding protein implicated in inflammatory signalling. Optineurin mutations are associated with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), neurodegenerative diseases characterised by neuronal loss, neuroinflammation, and peripheral immune disbalance. However, the pathogenic role of optineurin mutations is unclear. We previously observed no p...

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Literature Corpus work: 62fae655-081e-5894-9d93-87ebcc9e1154
DOI: 10.1101/2023.03.09.531905

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