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Article

Thymic involution perturbs negative selection leading to autoreactive T cells that induce chronic inflammation.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 2015

Coder Brandon D, Wang Hongjun, Ruan Linhui, Su Dong-Ming

Abstract excerpt

Thymic involution and the subsequent amplified release of autoreactive T cells increase the susceptibility toward developing autoimmunity, but whether they induce chronic inflammation with advanced age remains unclear. The presence of chronic low-level proinflammatory factors in elderly individuals (termed inflammaging) is a significant risk factor for morbidity and mortality in virtually every chronic...

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Identifiers

PMID: 25957168
DOI: 10.4049/jimmunol.1500082
PMCID: PMC4458423

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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