Article

Optineurin deficiency induces patchy hair loss but it is not sufficient to cause amyotrophic lateral sclerosis in mice

2021-12-23

Abstract excerpt

Genetic alterations and environmental factors contribute towards pathogenesis of amyotrophic lateral sclerosis (ALS), a neurodegenerative disease. Various types of mutations in the autophagy receptor protein optineurin (coded by OPTN gene) including deletions are causatively associated with ALS. To explore the role of OPTN in ALS pathogenesis, we used Optn knockout mice to study the features of ALS. The Optn-defi...

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Literature Corpus work: a11800c6-d193-5872-b98d-299bdf7acad3
DOI: 10.1101/2021.12.22.473616

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Optineurin deficiency induces patchy hair loss but it is not sufficient to cause amyotrophic lateral sclerosis in miceDOI 10.1101/2021.12.22.473616Read

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