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Article

Dysfunction of Optineurin in Amyotrophic Lateral Sclerosis and Glaucoma.

Frontiers in immunology - 1 Jan 2018

Toth Reka P, Atkin Julie D

Abstract excerpt

Neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS), frontotemporal dementia, and glaucoma, affect millions of people worldwide. ALS is caused by the loss of motor neurons in the spinal cord, brainstem, and brain, and genetic mutations are responsible for 10% of all ALS cases. Glaucoma is characterized by the loss of retinal ganglion cells and is the most common cause of irreversible...

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Share to Amyotrophic Lateral Sclerosis
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29875767
DOI: 10.3389/fimmu.2018.01017
PMCID: PMC5974248

Genes

OPTN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dysfunction of Optineurin in Amyotrophic Lateral Sclerosis and Glaucoma.PMID 29875767Read ↗

Functional analysis of optineurin and some of its disease-associated mutants.Semantic proximity Read ↗

Fundamental roles of the Optineurin gene in the molecular pathology of Amyotrophic Lateral SclerosisSemantic proximity Read ↗

Optineurin: A Coordinator of Membrane-Associated Cargo Trafficking and Autophagy.Semantic proximity Read ↗

Toward an integrative view of Optineurin functionsSemantic proximity Read ↗

Cellular Functions of Optineurin in Health and Disease.Semantic proximity Read ↗

Altered Functions and Interactions of Glaucoma-Associated Mutants of Optineurin.Semantic proximity Read ↗

Defects in autophagy caused by glaucoma-associated mutations in optineurin.Semantic proximity Read ↗

Optineurin, a multifunctional protein involved in glaucoma, amyotrophic lateral sclerosis and antiviral signalling.Semantic proximity Read ↗

Effects of mutations and deletions in the human optineurin geneSemantic proximity Read ↗

OPTN protects retinal ganglion cells and ameliorates neuroinflammation in optic neuropathiesSemantic proximity Read ↗

Role of Optineurin in the Mitochondrial Dysfunction: Potential Implications in Neurodegenerative Diseases and CancerSemantic proximity Read ↗

Optineurin in amyotrophic lateral sclerosis: Multifunctional adaptor protein at the crossroads of different neuroprotective mechanisms.Semantic proximity Read ↗

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