Article

Optineurin deficiency impairs autophagy to cause interferon beta overproduction and increased survival of mice following viral infection

2023-03-15

Abstract excerpt

<h4>Background</h4> Optineurin (OPTN) is associated with several human diseases, including amyotrophic lateral sclerosis (ALS), and is involved in various cellular processes, including autophagy. Optineurin regulates the expression of interferon beta (IFNβ), which plays a central role in the innate immune response to viral infection. However, the role of optineurin in response to viral infection has not been full...

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Literature Corpus work: 8878407b-fb6b-5b28-950e-9171f195a09e
DOI: 10.1101/2023.03.13.532484

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