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Article

Neuroimmune characterization of optineurin insufficiency mouse model during ageing.

Scientific reports - 22 Jul 2023

Mohovic Nikolina, Peradinovic Josip, Markovinovic Andrea, Cimbro Raffaello, Minic Zeljka, Dominovic Marin, Jakovac Hrvoje, Nimac Jerneja, Rogelj Boris, Munitic Ivana

Abstract excerpt

Optineurin is a multifunctional polyubiquitin-binding protein implicated in inflammatory signalling. Optineurin mutations are associated with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), neurodegenerative diseases characterised by neuronal loss, neuroinflammation, and peripheral immune disbalance. However, the pathogenic role of optineurin mutations is unclear. We previously observed no...

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Identifiers

PMID: 37481656
DOI: 10.1038/s41598-023-38875-3
PMCID: PMC10363168

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