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Article

Cellular Functions of Optineurin in Health and Disease.

Trends in immunology - 1 Sept 2016

Slowicka Karolina, Vereecke Lars, van Loo Geert

Abstract excerpt

Optineurin (OPTN) was initially identified as a regulator of NF-κB and interferon signaling, but attracted most attention because of its association with various human disorders such as glaucoma, Paget disease of bone, and amyotrophic lateral sclerosis. Importantly, OPTN has recently been identified as an autophagy receptor important for the autophagic removal of pathogens, damaged mitochondria, and protein...

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Identifiers

PMID: 27480243
DOI: 10.1016/j.it.2016.07.002

Genes

OPTN

Provenance

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cellular Functions of Optineurin in Health and Disease.PMID 27480243Read ↗

Toward an integrative view of Optineurin functionsSemantic proximity Read ↗

Emerging views of OPTN (optineurin) function in the autophagic process associated with diseaseSemantic proximity Read ↗

Optineurin: A Coordinator of Membrane-Associated Cargo Trafficking and Autophagy.Semantic proximity Read ↗

Role of Optineurin in the Mitochondrial Dysfunction: Potential Implications in Neurodegenerative Diseases and CancerSemantic proximity Read ↗

Dysfunction of Optineurin in Amyotrophic Lateral Sclerosis and Glaucoma.Semantic proximity Read ↗

Altered Functions and Interactions of Glaucoma-Associated Mutants of Optineurin.Semantic proximity Read ↗

Functional analysis of optineurin and some of its disease-associated mutants.Semantic proximity Read ↗

OPTN translocates to an ATG9A-positive compartment to regulate innate immune signalling and cytokine secretionSemantic proximity Read ↗

Fundamental roles of the Optineurin gene in the molecular pathology of Amyotrophic Lateral SclerosisSemantic proximity Read ↗

Optineurin deficiency impairs autophagy to cause interferon beta overproduction and increased survival of mice following viral infectionSemantic proximity Read ↗

Defects in autophagy caused by glaucoma-associated mutations in optineurin.Semantic proximity Read ↗

Optineurin Negatively Regulates Osteoclast Differentiation by Modulating NF-κB and Interferon Signaling: Implications for Paget’s DiseaseSemantic proximity Read ↗

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