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Targeting PKIA/cAMP-EPAC signaling overcomes vincristine resistance in Ewing sarcoma

2025-08-13

Abstract excerpt

<title>Abstract</title> <p>Ewing sarcoma (ES) is an aggressive bone malignancy with poor outcomes for chemotherapy-resistant patients, yet the mechanisms underlying vincristine resistance remain unclear. Here, we identify protein kinase inhibitor alpha (PKIA) as a critical driver of chemoresistance through cAMP-EPAC signaling reprogramming. Transcriptomic analysis of vincristine-resistant ES cells revealed PKIA u...

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Literature Corpus work
62f445d0-bbb3-5896-9104-d19af607f7fb
DOI
10.21203/rs.3.rs-7292052/v1
Open publication

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