Article

Targeting CXADR-mediated AKT signaling suppresses tumorigenesis and enhances chemotherapy efficacy in Ewing sarcoma

2025-08-10

Abstract excerpt

<h4>ABSTRACT</h4> Distant metastasis is the leading cause of mortality in Ewing sarcoma (EwS) – a malignant bone or soft-tissue cancer mainly affecting children, adolescents, and young adults. Despite continuous efforts in understanding its pathogenesis, the molecular mechanisms driving EwS metastasis remain poorly understood, thus limiting the potential for therapeutic progress. Here, we identify the tight junct...

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Literature Corpus work: b54893ac-2180-51e6-8957-28e717163356
DOI: 10.1101/2025.08.07.669049

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