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Article

Establishment and characterization of 18 Sarcoma Cell Lines: Unraveling the Molecular Mechanisms of Doxorubicin Resistance in Sarcoma Cell Lines.

Journal of translational medicine - 2 Oct 2024

Cho Young-Eun, Kim Soon-Chan, Kim Ha Jeong, Han Ilkyu, Ku Ja-Lok

Abstract excerpt

Sarcomas, malignant tumors from mesenchymal tissues, exhibit poor prognosis despite advancements in treatment modalities such as surgery, radiotherapy, and chemotherapy, with doxorubicin being a cornerstone treatment. Resistance to doxorubicin remains a significant hurdle in therapy optimization. This study aims to dissect the molecular bases of doxorubicin resistance in sarcoma cell lines, which could guide the...

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Aged
Cell Line, Tumor
Doxorubicin
Drug Resistance, Neoplasm
Gene Expression Profiling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gene Expression Regulation, Neoplastic

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PMID: 39358756
DOI: 10.1186/s12967-024-05700-y
PMCID: PMC11445991

Genes

TP53

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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