Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sensitizing Ewing sarcoma to chemo- and radiotherapy by inhibition of the DNA-repair enzymes DNA protein kinase (DNA-PK) and poly-ADP-ribose polymerase (PARP) 1/2

28 Sept 2017

Abstract excerpt

// Britta Vormoor 1, 2 , Yvonne T. Schlosser 3 , Helen Blair 1 , Abhishek Sharma 4 , Sarah Wilkinson 5 , David R. Newell 6 and Nicola Curtin 6 1 Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK 2 Department of Paediatric and Adolescent Haematology and Oncology, Great North Children’s Hospital, Newcastle upon Tyne Hospitals NHS...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Repair Mechanisms
Share to Effects of Radiation Exposure
Share to PARP inhibition in cancer therapy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29371919
DOI: 10.18632/oncotarget.21300

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sensitizing Ewing sarcoma to chemo- and radiotherapy by inhibition of the DNA-repair enzymes DNA protein kinase (DNA-PK) and poly-ADP-ribose polymerase (PARP) 1/2PMID 29371919Read ↗

The PARP inhibitor olaparib enhances the sensitivity of Ewing sarcoma to trabectedinSemantic proximity Read ↗

Efficacy of ATR inhibitors as single agents in Ewing sarcomaSemantic proximity Read ↗

Combinations of PARP Inhibitors with Temozolomide Drive PARP1 Trapping and Apoptosis in Ewing’s SarcomaSemantic proximity Read ↗

Molecular targets that sensitize cancer to radiation killing: From the bench to the bedsideSemantic proximity Read ↗

Activity of trabectedin and the PARP inhibitor rucaparib in soft-tissue sarcomasSemantic proximity Read ↗

Targeting DNA double strand break repair with hyperthermia and DNA-PKcs inhibition to enhance the effect of radiation treatmentSemantic proximity Read ↗

Doxycycline down-regulates DNA-PK and radiosensitizes tumor initiating cells: Implications for more effective radiation therapySemantic proximity Read ↗

Common cancer-associated imbalances in the DNA damage response confer sensitivity to single agent ATR inhibitionSemantic proximity Read ↗

Enhancing Standard of Care Chemotherapy Efficacy Using DNA-Dependent Protein Kinase (DNA-PK) Inhibition in Preclinical Models of Ewing SarcomaSemantic proximity Read ↗

Unravelling homologous recombination repair deficiency and therapeutic opportunities in soft tissue and bone sarcomaSemantic proximity Read ↗

Targeting the DNA Repair Pathway in Ewing SarcomaSemantic proximity Read ↗

Emerging novel agents for patients with advanced Ewing sarcoma: a report from the Children’s Oncology Group (COG) New Agents for Ewing Sarcoma Task ForceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.