Article

Histone deacetylase activity limits the response to EZH2 inhibition-based therapy in epithelioid sarcoma and is targetable by epigenetic combination

2026-08-20

Abstract excerpt

<title>Abstract</title> <p> Background. Epithelioid sarcoma (EpS) is an ultra-rare, aggressive soft tissue sarcoma (STS) driven by loss of the tumor suppressor INI1, encoded by <italic>SMARCB1</italic> , which triggers hyperactivation of the chromatin-modifying enzyme EZH2. However, objective responses to the EZH2 inhibitor (EZH2i) tazemetostat (TZM) remain limited to approximately 15% of patients. Combinatio...

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Literature Corpus work: 40cfbc05-8bec-5678-88d8-12c2e4fe9651
DOI: 10.21203/rs.3.rs-10655068/v1

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