Article

Reverse molecular pharmacology identifies the non-canonical axis of IRAK as a chemoresistance factor in neuroblastoma

2026-01-09

Abstract excerpt

Owing to chemoresistance, the prognosis of relapsed neuroblastoma is dismal with less than 10% of patients surviving after 5 years. We developed a reverse molecular pharmacology approach that is based on high-throughput drug screening coupled with chemo-informatic and transcriptomic analyses. This led to the identification of IRAK1 as a key chemoresistance factor in neuroblastoma. By performing functional and phar...

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Literature Corpus work: 89262b8f-dc0f-563d-9f3d-a09e8ea28d1b
DOI: 10.64898/2026.01.09.697473

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