Article

Collagen Production and Niche Engineering: A Novel Strategy for Cancer Cells to Survive Acidosis and Evolve

2019-07-24

Abstract excerpt

<h4>Summary</h4> Ductal Carcinoma in situ (DCIS) is an avascular disease characterized by profound acidosis. Pre-malignant cells within this niche must adapt to acidosis to survive and thrive. A component of this acid-adaptation involves extracellular matrix remodeling leading to niche construction and remodeling. Using discovery proteomics, we identified that collagen producing enzyme PLODs are upregulated in ac...

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Literature Corpus work: b99e847d-3aa4-5a98-950a-4c5e7cfd3c6a
DOI: 10.1101/711978

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