Article

Acidic microenvironment shaped by lactate accumulation promotes pluripotency through multiple mechanisms

2018-03-15

Abstract excerpt

Enhanced glycolysis is a distinct feature associated with numerous stem cells and cancer cells. However, little is known about its regulatory roles in gene expression and cell fate determination. Here we show that acidic environment shaped by lactate accumulation promotes the self-renewal and pluripotency of both mouse and human embryonic stem cells (ESCs). Mechanistically, acidic pH reduces the tri-methylation of...

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Literature Corpus work: ac0c2792-aa84-5759-a845-32a27dd0e48b
DOI: 10.1101/282475

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