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Article

The Aging Synapse: An Integrated Proteomic And Transcriptomic Analysis

2024-12-20

Abstract excerpt

<h4>ABSTRACT</h4> An important hallmark of aging is the loss of proteostasis, which can lead to the formation of protein aggregates and mitochondrial dysfunction in neurons. Although it is well known that protein synthesis is finely regulated in the brain, especially at synapses, where mRNAs are locally translated in activity-dependent manner, little is known as to the changes in the synaptic proteome and transcr...

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Literature Corpus work
62cbcbcc-0470-54a9-8a5c-79dfdb2ff81c
DOI
10.1101/2024.12.18.629115
Open publication

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The Aging Synapse: An Integrated Proteomic And Transcriptomic AnalysisDOI 10.1101/2024.12.18.629115
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