Article

Altered transcriptome-proteome coupling indicates aberrant proteostasis in Parkinson’s disease

2021-03-20

Abstract excerpt

The correlation between mRNA and protein levels has been shown to decline in the ageing brain, possibly reflecting age-dependent changes in the proteostasis. It is thought that impaired proteostasis may be implicated in the pathogenesis of Parkinson’s disease (PD), but evidence derived from the patient brain is currently limited. Here, we hypothesized that if impaired proteostasis occurs in PD, this should be refl...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 247dc631-b0db-52e5-be29-511e985d2069
DOI: 10.1101/2021.03.18.21253875

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Altered transcriptome-proteome coupling indicates aberrant proteostasis in Parkinson’s diseaseDOI 10.1101/2021.03.18.21253875Read

Altered transcriptome-proteome coupling indicates aberrant proteostasis in Parkinson’s diseaseSemantic proximity Read

A review of genome‐wide transcriptomics studies in Parkinson's diseaseSemantic proximity Read

Integrative analyses of proteomics and RNA transcriptomics implicate mitochondrial processes, protein folding pathways and GWAS loci in Parkinson disease.Semantic proximity Read

Synaptic proteostasis in Parkinson's disease.Semantic proximity Read

Transcriptome analysis reveals link between proteasomal and mitochondrial pathways in Parkinson’s diseaseSemantic proximity Read

Systems-Based Analyses of Brain Regions Functionally Impacted in Parkinson's Disease Reveals Underlying Causal MechanismsSemantic proximity Read

Transcriptomic profiling of Parkinson's disease brains reveals disease stage specific gene expression changesSemantic proximity Read

Gene Expression Profiling of Post Mortem Midbrain of Parkinson’s Disease Patients and Healthy ControlsSemantic proximity Read

Transcriptomics and weighted protein network analysis of the LRRK2 protein interactome reveal distinct molecular signatures for sporadic and LRRK2 Parkinson’s DiseaseSemantic proximity Read

New molecular signatures defining the differential proteostasis response in ALS-resistant and -sensitive motor neuronsSemantic proximity Read

Common gene expression signatures in Parkinson’s disease are driven by changes in cell compositionSemantic proximity Read

The Aging Synapse: An Integrated Proteomic And Transcriptomic AnalysisSemantic proximity Read