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Article

Disease-associated mutations affect TIA1 phase separation and aggregation in a proline-dependent manner.

Brain research - 1 Oct 2021

Ding Xiufang, Gu Siyu, Xue Song, Luo Shi-Zhong

Abstract excerpt

T-cell restriction intracellular antigen 1 (TIA1) is an RNA-binding protein that is a major component of stress granules (SGs). The low complexity domain (LCD) of TIA1 plays a central role in facilitating SGs assembly through liquid-liquid phase separation (LLPS). Disruption of the LLPS process has been associated with several diseases. It has recently been shown that the proline-rich domain affects the LLPS...

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Identifiers

PMID: 34310938
DOI: 10.1016/j.brainres.2021.147589

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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