Article

ALS mutations in the TIA1 RNA granule protein have differing effect on low complexity domain fibril formation

2026-05-18

Abstract excerpt

Mutations in the low complexity domains of RNA-binding proteins are associated with neurodegenerative disease pathology. The TIA1 RNA-binding protein harbors seven such mutations linked to a clinical cohort of ALS patients. The altered low complexity domain sequence increases the number of TIA1-rich stress granules in cultured cells, delays their disassembly, and is associated with increased fibril formation. Alte...

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Literature Corpus work: fdd1db4d-163f-5802-a755-f5dafd1ad1ed
DOI: 10.64898/2026.05.18.725988

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