Article

Human plasma cells engineered to secrete bispecifics drive effective <i>in vivo</i> leukemia killing

2023-08-27

Abstract excerpt

Bispecific antibodies are an important tool for the management and treatment of acute leukemias. Advances in genome-engineering have enabled the generation of human plasma cells that secrete therapeutic proteins and are capable of long-term in vivo engraftment in humanized mouse models. As a next step towards clinical translation of engineered plasma cells (ePCs) towards cancer therapy, here we describe approache...

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Identifiers and source

Literature Corpus work: 8dd76e79-96d8-50fd-9b07-67fa25ab3996
DOI: 10.1101/2023.08.24.554523

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