Article

Integrative analysis of viral entry networks and clinical outcomes identifies a protective role for spironolactone in severe COVID-19

2022-07-06

Abstract excerpt

<h4>ABSTRACT</h4> Treatment strategies that target host entry factors have proven an effective means of impeding viral entry in HIV and may be more robust to viral evolution than drugs targeting viral proteins directly. High-throughput functional screens provide an unbiased means of identifying genes that influence the infection of host cells, while retrospective cohort analysis can measure the real-world, clinica...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 62b9cdb9-f00a-596f-812c-3a5197057a84
DOI: 10.1101/2022.07.02.22277181

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Integrative analysis of viral entry networks and clinical outcomes identifies a protective role for spironolactone in severe COVID-19DOI 10.1101/2022.07.02.22277181Read

Integrative Analysis of Functional Genomic Screening and Clinical Data Identifies a Protective Role for Spironolactone in Severe COVID-19Semantic proximity Read

A genetically based computational drug repurposing framework for rapid identification of candidate compounds: application to COVID-19Semantic proximity Read

Host - virus - drug interactions as determinants of COVID-19's phenotypes: A data-driven hypothesis.Semantic proximity Read

Tripartite combination of potential pandemic mitigation agents: Vitamin D, Quercetin, and Estradiol manifest properties of candidate medicinal agents for mitigation of the severity of pandemic COVID-19 defined by genomics-guided tracing of SARS-CoV-2 targets in human cells.Semantic proximity Read

Genetic determinants of COVID-19 drug efficacy revealed by genome-wide CRISPR screensSemantic proximity Read

Association between spironolactone use and COVID-19 outcomes in population-scale claims data: a retrospective cohort studySemantic proximity Read

A Quantitative Genetic Interaction Map of HIV Infection.Semantic proximity Read

A Virus-Packageable CRISPR System Identifies Host Dependency Factors Across Multiple HIV-1 StrainsSemantic proximity Read

SPLIT: Safety Prioritization for Long COVID Drug Repurposing via a Causal Integrated Targeting FrameworkSemantic proximity Read

Connecting the dots: applications of network medicine in pharmacology and disease.Semantic proximity Read

A functional map of HIV-host interactions in primary human T cellsSemantic proximity Read

Repurposing screen identifies novel candidates for broad-spectrum coronavirus antivirals and druggable host targetsSemantic proximity Read