Article

A genetically based computational drug repurposing framework for rapid identification of candidate compounds: application to COVID-19

2025-01-14

Abstract excerpt

<h4>Background</h4> The development and approval of novel drugs are typically time-intensive and expensive. Leveraging a computational drug repurposing framework that integrates disease-relevant genetically regulated gene expression (GReX) and large longitudinal electronic medical record (EMR) databases can expedite the repositioning of existing medications. However, validating computational predictions of the dr...

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Literature Corpus work: 4a6841ef-88a4-580a-bdda-4922a608095c
DOI: 10.1101/2025.01.10.25320348

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