Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Host - virus - drug interactions as determinants of COVID-19's phenotypes: A data-driven hypothesis.

Medical hypotheses - 1 Nov 2020

Vavougios George D

Abstract excerpt

There is a growing body of evidence on the significance of interactions between comorbidities, their treatments and COVID-19 clinical phenotypes. The hypothesis explored herein is that pharmaceutical compounds currently in use are affecting COVID-19 susceptibility and phenotypes by overlapping transcriptional networks. Using two distinct SARS-CoV-2 - host interactomes, gene set enrichment analysis is used to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Angiotensin-Converting Enzyme 2
Share to COVID-19
Share to Gene Expression Regulation, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Host-Pathogen Interactions

Share to Immune System

Share to Micronutrients

Share to Models, Theoretical

Share to SARS-CoV-2

Source

Open in PubMed Open full text

Identifiers

PMID: 33254579
DOI: 10.1016/j.mehy.2020.110275
PMCID: PMC7494558

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Host - virus - drug interactions as determinants of COVID-19's phenotypes: A data-driven hypothesis.PMID 33254579Read ↗

Potential Genes Associated with COVID-19 and Comorbidity.Semantic proximity Read ↗

Comorbidities and Susceptibility to COVID-19: A Generalized Gene Set Meta-Analysis ApproachSemantic proximity Read ↗

A systems‐level study reveals host‐targeted repurposable drugs against SARS‐CoV‐2 infectionSemantic proximity Read ↗

Network-Based Analysis of Fatal Comorbidities of COVID-19 and Potential TherapeuticsSemantic proximity Read ↗

Transcriptomic Analysis of the Peripheral Immune Cell of SARS-CoV-2 Infected Patients for Bridging the Genotype-Phenotype Gap and Drug Prediction: A Precision Medicine ApproachSemantic proximity Read ↗

Identification of pulmonary comorbid diseases network based repurposing effective drugs for COVID-19Semantic proximity Read ↗

Prediction of severe adverse events, modes of action and drug treatments for COVID-19's complications.Semantic proximity Read ↗

Multi-ancestry omic Mendelian randomization revealing putative drug targets of COVID-19 severitySemantic proximity Read ↗

Recognition of plausible therapeutic agents to combat COVID-19: An omics data based combined approachSemantic proximity Read ↗

Investigation of COVID-19 comorbidities reveals genes and pathways coincident with the SARS-CoV-2 viral diseaseSemantic proximity Read ↗

Investigation of COVID-19 comorbidities reveals genes and pathways coincident with the SARS-CoV-2 viral diseaseSemantic proximity Read ↗

A genetically based computational drug repurposing framework for rapid identification of candidate compounds: application to COVID-19Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.