Article

A Virus-Packageable CRISPR System Identifies Host Dependency Factors Across Multiple HIV-1 Strains

2022-11-04

Abstract excerpt

At each stage of the HIV life cycle, host cellular proteins are hijacked by the virus to establish and enhance infection. We adapted the virus packageable HIV-CRISPR screening technology at a genome-wide scale to comprehensively identify host factors that affect HIV replication in a human T cell line. Using a smaller, targeted HIV Dependency Factor (HIVDEP) sub-library, we then performed screens across multiple HI...

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Identifiers and source

Literature Corpus work: f232b5df-d67b-59d6-bfce-56caa5d965c0
DOI: 10.1101/2022.11.03.515041

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