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Tripartite combination of potential pandemic mitigation agents: Vitamin D, Quercetin, and Estradiol manifest properties of candidate medicinal agents for mitigation of the severity of pandemic COVID-19 defined by genomics-guided tracing of SARS-CoV-2 targets in human cells.

2020-05-13

Abstract excerpt

Genes required for SARS-CoV-2 entry into human cells, ACE2 and FURIN , were employed as baits to build genomics-guided molecular maps of up-stream regulatory elements, their expression and functions in human body, including pathophysiologically-relevant cell types. Repressors and activators of the ACE2 and FURIN genes were identified based on the analyses of gene silencing and overexpression experiments as wel...

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Literature Corpus work
4c926f26-36df-522b-a571-570bbadc0143
DOI
10.26434/chemrxiv.12052512.v11
Open publication

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Tripartite combination of potential pandemic mitigation agents: Vitamin D, Quercetin, and Estradiol manifest properties of candidate medicinal agents for mitigation of the severity of pandemic COVID-19 defined by genomics-guided tracing of SARS-CoV-2 targets in human cells.DOI 10.26434/chemrxiv.12052512.v11
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