Article

Integrative Analysis of Functional Genomic Screening and Clinical Data Identifies a Protective Role for Spironolactone in Severe COVID-19

2022-11-11

Abstract excerpt

The emergence of SARS-CoV-2 variants with resistance to existing COVID-19 treatments and evasion from prior vaccination reinforces the need for drugs targeting host entry factors. Targeting host pathways have proven an effective means of impeding viral entry in HIV, and may be more robust to viral evolution. Nonetheless, there is a lack for methods that rapidly and systematically identify host-targeting drugs for...

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Literature Corpus work: 7968a5d4-ef66-5938-a88c-774c249f0361
DOI: 10.2139/ssrn.4272135

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