repgenHMM: a dynamic programming tool to infer the rules of immune receptor generation from sequence data

Abstract excerpt

The diversity of the immune repertoire is initially generated by random rearrangements of the receptor gene during early T and B cell development. Rearrangement scenarios are composed of random events – choices of gene templates, base pair deletions and insertions – described by probability distributions. Not all scenarios are equally likely, and the same receptor sequence may be obtained in several different ways...

Topics

Open a Topic to create a Post that cites this publication.

• CAR-T cell therapy research
• Immune Cell Function and Interaction
• Monoclonal and Polyclonal Antibodies Research
• T-cell and B-cell Immunology
• vaccines and immunoinformatics approaches

Identifiers and source

Literature Corpus work

10244558-dc14-5268-8a13-700a13a17bc8

DOI

10.1101/030403