Article

Quantitation and Characterization of Cell-Free Mitochondrial DNA in Plasma by Deep Sequencing

2021-07-09

Abstract excerpt

The presence in plasma of mitochondrial DNA (mtDNA) fragments, a proinflammatory damage-associated molecular pattern (DAMP), is positively associated with outcomes of multiple human disorders. Because mtDNA comprises only a small percentage of the total DNA in plasma, qPCR is typically employed as an analytic strategy. However, this method provides little insight into sequence origins or other characteristics of c...

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Literature Corpus work: 62a2f667-326d-511f-ad79-3d4e0dcbae86
DOI: 10.21203/rs.3.rs-668341/v1

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