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Investigating the impact of mitochondrial DNA : Insights into blood transfusion reactions and mitigation strategies

8 Jan 2025

Abstract excerpt

BACKGROUND AND OBJECTIVES: Although transfusion reactions occur in less than 2% of recipients, they are currently one of the most serious concerns in blood transfusion. Damage-associated molecular patterns (DAMPs) are released from injured, stressed or dead cells, leading to inflammation and immune system activation. One of the recognized DAMPs is mitochondrial DNA (mtDNA). It is found in various blood products,...

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PMID: 39778582
DOI: 10.1111/vox.13794

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