Article

Aberrant fragmentomic features of circulating cell-free mitochondrial DNA as novel biomarkers in cancer patients

2023-12-07

Abstract excerpt

Fragmentomic features of circulating cell free mitochondrial DNA (ccf-mtDNA) including fragmentation profile, 5’ end base preference and motif diversity are poorly understood. Here, we generated sequencing data in 788 plasma samples and found that fragmentomic features of ccf-mtDNA were remarkably different from those of circulating cell free nuclear DNA. Furthermore, region-specific fragmentomic features were obs...

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Literature Corpus work: 26dc8cdb-8cab-580d-b418-dbd1aca54ed7
DOI: 10.21203/rs.3.rs-3620407/v1

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