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Comparison of the structures and topologies of plasma extracted circulating nuclear and mitochondrial cell-free DNA

20 Apr 2023

Abstract excerpt

Introduction: The function, origin and structural features of circulating nuclear DNA (cir-nDNA) and mitochondrial DNA (cir-mtDNA) are poorly known, even though they have been investigated in numerous clinical studies, and are involved in a number of routine clinical applications. Based on our previous report disproving the conventional plasma isolation used for cirDNA analysis, this work enables a direct...

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PMID: 37152979
DOI: 10.3389/fgene.2023.1104732

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