Article

Serum mtDNA DAMP abundance, fragmentation and heteroplasmic variants associate with Acute Respiratory Failure outcome: A secondary analysis of study NCT00976833

2025-08-28

Abstract excerpt

<h4>Background</h4> Serum mitochondrial DNA (mtDNA) fragments act as proinflammatory damage-associated molecular patterns (DAMPs), and have been linked to outcomes in critical illness. However, their prognostic value remains uncertain, possibly due to confounding nuclear mitochondrial insertions (NUMTs) which obscure both quantitation and variant detection. <h4>Methods</h4> Using a targeted deep sequencing and b...

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Literature Corpus work: 7fe444fe-0c45-535b-9206-330fee065a55
DOI: 10.1101/2025.08.26.25334376

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