Article
Assessing mitochondrial heteroplasmy using next generation sequencing: A note of caution.
Mitochondrion - 1 May 2019
Santibanez-Koref Mauro, Griffin Helen, Turnbull Douglass M, Chinnery Patrick F, Herbert Mary, Hudson Gavin
Abstract excerpt
The mitochondrial genome has recently become the focus of several high-impact next-generation sequencing studies investigating the effect of mutations in disease and assessing the efficacy of mitochondrial replacement therapies. However, these studies have failed to take into consideration the capture of recurring translocations of mitochondrial DNA to the nuclear genome, known as nuclear mitochondrial sequences...
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