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Article

Transcriptomic profiling identifies immunotherapy-responsive phenotypes in microsatellite-stable metastatic colorectal cancer.

Oncogene - 1 Aug 2026

Konecny Tomas, Zadirako Nate, Grigoryan Arpine, Tamazyan Melina, Mnatsakanyan Sveta, Stepanyan Luiza, Loeffler-Wirth Henry, Bourdelais Sean, Mednick Gabriel, Delepine Chloe, Chand Dhan, Binder Hans

Abstract excerpt

Conventional immune checkpoint inhibitors (ICIs) remain largely ineffective in microsatellite-stable metastatic colorectal cancer (MSS mCRC), where low tumor immunogenicity and molecular heterogeneity across metastatic sites underpin therapeutic resistance. We present a comprehensive transcriptomics analysis of metastatic and primary tumor biopsies from MSS mCRC patients treated with botensilimab (BOT;...

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Share to Colorectal Neoplasms
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42298180
DOI: 10.1038/s41388-026-03861-2
PMCID: PMC13364656

Genes

CD74

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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