Article

Ontogeny drives stage-specific effects of a Gata1 mutation

2025-01-16

Abstract excerpt

<h4>Summary</h4> The biography of an organism, including, for instance, its genetic background and exposure to environmental influences, determines the penetrance and expressivity of monogenic diseases between individuals. This also applies at the single-cell level. Interestingly, mature blood and immune cells originate from anatomically and temporally distinct stem and progenitor populations at different stages...

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Literature Corpus work: 626d0c52-9cf7-5a7f-8704-d71d3efb06b1
DOI: 10.1101/2025.01.15.633164

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