Article

Oncogenic <i>Gata1</i> causes stage-specific megakaryocyte differentiation delay

2019-10-03

Abstract excerpt

The megakaryocyte/erythroid Transient Myeloproliferative Disorder (TMD) in newborns with Down Syndrome (DS) occurs when N-terminal truncating mutations of the hemopoietic transcription factor GATA1, that produce GATA1short protein (GATA1s), are acquired early in development. Prior work has shown that murine GATA1s, by itself, causes a transient yolk sac myeloproliferative disorder. However, it is unclear where in...

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Literature Corpus work: 86277ad0-2996-59f5-aaed-415fc17f2729
DOI: 10.1101/791079

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