Article
GATA Transcription Factors: Basic Principles and Related Human Disorders.
The Tohoku journal of experimental medicine - 1 Jun 2017
Fujiwara Tohru
Abstract excerpt
The development of mature blood cell from hematopoietic stem cells is regulated by transcription factors that coordinate the expression of lineage-specific genes. GATA transcription factors are zinc finger DNA-binding proteins that play crucial roles in various biological processes, including hematopoiesis. Among GATA family proteins, GATA-1, GATA-2, and GATA-3 are essential for hematopoiesis. GATA-1 functions to...
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