Article
Blood originates in hypoblasts during embryonic development
2025-11-07
Abstract excerpt
Blood is essential for oxygen supply throughout life. The emergence of blood in the human embryo remains poorly understood. Our study leverages multiple stem cell embryo models and advanced lineage barcoding to unveil that hypoblast, originally regarded as forming the yolk sac wall, is heterogeneous and contributes to CDX2+ extraembryonic mesoderm, followed by hemoglobin+ cells as the first blood cells. CDX2 marks...
Topics
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- Erythrocyte Function and Pathophysiology
- Erythropoietin and Anemia Treatment
- Hematopoietic Stem Cell Transplantation
- Hemoglobinopathies and Related Disorders
- Immune Cell Function and Interaction
- Neonatal Respiratory Health Research
- Single-cell and spatial transcriptomics
- Zebrafish Biomedical Research Applications
Identifiers and source
- Literature Corpus work
- 81959bd7-ef5b-55de-b48a-b5a48e5f44d3
- DOI
- 10.1101/2025.11.07.687183