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<i>Trypanosoma brucei</i> ribonuclease H2A is an essential enzyme that resolves R-loops associated with transcription initiation and antigenic variation

2019-02-05

Abstract excerpt

In every cell ribonucleotides represent a threat to the stability and transmission of the DNA genome. Two types of Ribonuclease H (RNase H) tackle such ribonucleotides, either by excision when they form part of the DNA strand, or by hydrolysing RNA when it base-pairs with DNA, in structures termed R-loops. Loss of either RNase H is lethal in mammals, whereas yeast can prosper in the absence of both enzymes. Remova...

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Literature Corpus work
626652b3-9ca6-5722-958e-6132f229eb69
DOI
10.1101/541300
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