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T rypanosoma brucei histone H 1 inhibits RNA polymerase I transcription and is important for parasite fitness in vivo

19 Jun 2014

Abstract excerpt

Trypanosoma brucei is a unicellular parasite that causes sleeping sickness in humans. Most of its transcription is constitutive and driven by RNA polymerase II. RNA polymerase I (Pol I) transcribes not only ribosomal RNA genes, but also protein-encoding genes, including variant surface glycoproteins (VSGs) and procyclins. In T. brucei, histone H1 (H1) is required for VSG silencing and chromatin condensation....

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PMID: 24946224
DOI: 10.1111/mmi.12677

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