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Telomere maintenance in African trypanosomes

24 Nov 2023

Abstract excerpt

Telomere maintenance is essential for genome integrity and chromosome stability in eukaryotic cells harboring linear chromosomes, as telomere forms a specialized structure to mask the natural chromosome ends from DNA damage repair machineries and to prevent nucleolytic degradation of the telomeric DNA. In Trypanosoma brucei and several other microbial pathogens, virulence genes involved in antigenic variation, a...

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PMID: 38074093
DOI: 10.3389/fmolb.2023.1302557

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