Article

Genetically determined platelet traits impact stroke risk through multiple mechanisms and cell types

2025-08-05

Abstract excerpt

Stroke remains a leading cause of death and disability worldwide. Current antiplatelet and anticoagulant treatments are prone to failure. Heritable blood and platelet traits contribute to stroke risk, but related mechanisms are not fully understood. Platelets bind to damaged endothelial walls to initiate thrombosis, but erythrocyte and leukocyte recruitment are involved in stroke pathogenesis. We aimed to identify...

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Literature Corpus work: 62557946-11ec-55d3-bc09-6e312a6180d9
DOI: 10.1101/2025.08.01.25332822

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