A genome- and phenome-wide association study to identify genetic variants influencing platelet count and volume and their pleiotropic effects.

doi:10.1007/s00439-013-1355-7

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Article

A genome- and phenome-wide association study to identify genetic variants influencing platelet count and volume and their pleiotropic effects.

Human genetics - 1 Jan 2014

Shameer Khader, Denny Joshua C, Ding Keyue, Jouni Hayan, Crosslin David R, de Andrade Mariza, Chute Christopher G, Peissig Peggy, Pacheco Jennifer A, Li Rongling, Bastarache Lisa, Kho Abel N, Ritchie Marylyn D, Masys Daniel R, Chisholm Rex L, Larson Eric B, McCarty Catherine A, Roden Dan M, Jarvik Gail P, Kullo Iftikhar J

Abstract excerpt

Platelets are enucleated cell fragments derived from megakaryocytes that play key roles in hemostasis and in the pathogenesis of atherothrombosis and cancer. Platelet traits are highly heritable and identification of genetic variants associated with platelet traits and assessing their pleiotropic effects may help to understand the role of underlying biological pathways. We conducted an electronic medical record...

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Identifiers

PMID: 24026423
DOI: 10.1007/s00439-013-1355-7
PMCID: PMC3880605

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