Genetic variants associated with platelet count are predictive of human disease and physiological markers.

doi:10.1038/s42003-021-02642-9

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Article

Genetic variants associated with platelet count are predictive of human disease and physiological markers.

Communications biology - 27 Sept 2021

Mikaelsdottir Evgenia, Thorleifsson Gudmar, Stefansdottir Lilja, Halldorsson Gisli, Sigurdsson Jon K, Lund Sigrun H, Tragante Vinicius, Melsted Pall, Rognvaldsson Solvi, Norland Kristjan, Helgadottir Anna, Magnusson Magnus K, Ragnarsson Gunnar B, Kristinsson Sigurdur Y, Reykdal Sigrun, Vidarsson Brynjar, Gudmundsdottir Ingibjorg J, Olafsson Isleifur, Onundarson Pall T, Sigurdardottir Olof, Sigurdsson Emil L, Grondal Gerdur, Geirsson Arni J, Geirsson Gudmundur, Gudmundsson Julius, Holm Hilma, Saevarsdottir Saedis, Jonsdottir Ingileif, Thorgeirsson Gudmundur, Gudbjartsson Daniel F, Thorsteinsdottir Unnur, Rafnar Thorunn, Stefansson Kari

Abstract excerpt

Platelets play an important role in hemostasis and other aspects of vascular biology. We conducted a meta-analysis of platelet count GWAS using data on 536,974 Europeans and identified 577 independent associations. To search for mechanisms through which these variants affect platelets, we applied cis-expression quantitative trait locus, DEPICT and IPA analyses and assessed genetic sharing between platelet count...

Topics

Biomarkers
Female
Genetic Variation
Humans
Male
Phenotype
Platelet Count

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Quantitative Trait Loci

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Identifiers

PMID: 34580418
DOI: 10.1038/s42003-021-02642-9
PMCID: PMC8476563

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