Article

Genome Sequencing Unveils a New Regulatory Landscape of Platelet Reactivity

2019-05-16

Abstract excerpt

Exaggerated platelet aggregation at the site of vascular injury is the underlying pathophysiology of thrombotic diseases. Here, we conduct the largest whole genome sequencing (WGS) effort to uncover the genetic determinants of platelet aggregation. Leveraging 3,855 NHLBI Trans-Omics for Precision Medicine (TOPMed) individuals deeply phenotyped for platelet aggregation, we identify 18 loci using single-variant appr...

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Literature Corpus work: 425c8a75-7d56-5c03-9621-968eb19c1f90
DOI: 10.1101/621565

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