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Article

Shared genetic architecture between stroke and blood lipids: a large-scale genome-wide cross-trait analysis.

Human genomics - 3 Jul 2025

Bai Wenya, Zhou Guilin, Jiang Huan, Li Xuelian, Shao Jianlin

Abstract excerpt

BACKGROUND: Blood lipid levels are linked to stroke risk, but the genetic correlation between blood lipids and stroke is not well understood. We investigated the shared genetic architecture between blood lipids and stroke, including its subtypes, identifying common risk loci, genes, and underlying genetic mechanisms. METHODS: Utilizing large-scale genome-wide association study (GWAS) summary data, we identified...

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Share to Genetic Pleiotropy
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Linkage Disequilibrium

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Share to Mendelian Randomization Analysis

Share to Polymorphism, Single Nucleotide

Share to Quantitative Trait Loci

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Source

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Identifiers

PMID: 40605082
DOI: 10.1186/s40246-025-00789-8
PMCID: PMC12224841

Genes

SH2B3
ALDH2
CUX2
ICA1L
TG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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