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Article

Genetic Evidence That Stroke Causally Increases Circulating PDGFB Levels: a Two-Sample Mendelian Randomization Study.

Journal of molecular neuroscience : MN - 5 Sept 2026

Luo Ying, Zhu QingFeng, Zhang Linjie, Mo DanHeng

Abstract excerpt

Platelet-derived growth factor subunit B (PDGFB) is a key regulator of vascular remodeling, angiogenesis, and blood-brain barrier integrity. Although elevated PDGFB levels have been reported after ischemic injury, whether stroke liability itself causally influences circulating PDGFB levels remains unclear. We performed a two-sample Mendelian randomization (MR) analysis to assess the causal effects of genetically...

Read the complete abstract on PubMed

Topics

Humans
Mendelian Randomization Analysis
Stroke
Proto-Oncogene Proteins c-sis
Polymorphism, Single Nucleotide
Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 42700318
DOI: 10.1007/s12031-026-02595-w

Genes

PDGFB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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